A rhesus monkey model of common carotid stenosis

作者：Ye, Ziming; Liu, Ying; Wang, Xiawei; Chen, Xiangren; Lin, Cuiting; Su, Ying; Wang, Tianbao; Tang, Yanyan; Wu, Yuan; Qin, Chao^*

来源：International Journal of Clinical and Experimental Medicine, 2016, 9(9): 17487-17497.

• Common carotid stenosis
• common carotid arteries
• model
• rhesus monkey
• balloon injury
• high-fat

Objective: There are no common carotid stenosis (CCS) models in non-human primate animals yet. In this study, we combined the balloon injury in the left common carotid arteries (CCAs) with fat-rich feeding to establish a CCS model in the aged rhesus monkeys. Methods: Sixteen aged rhesus monkeys (14-18 years, 7.6-10.7 kg) were averagely allocated into the model and control groups, respectively. All the monkeys were made balloon injury in the left CCAs, and moneys in the model and control groups received high-fat food and normal food, respectively. At baseline and 20 weeks after the operation, the body weight and serum levels of blood lipids were measured. CCS and hemodynamic changes of CCAs were detected by the ultrasound and digital subtraction angiography (DSA) examinations, respectively. Results: Twenty weeks later after the operation, the model group monkeys exhibited apparent CCS in the left CCAs with an average CCS extent of 44.99 +/- 3.93%, while the control group did not (P<0.001). Significantly decreased arterial lumen diameter and increased systolic and diastolic peak velocity were observed in the model group relative to control group at 20 weeks as well as to model group at baseline (all P<0.05). Furthermore, there was significant difference in mean transit time, time to peak, and time of appearance of peak value on DSA images between the model and control groups (all P<0.05). Conclusions: The combination of balloon injury with fat-rich feeding for 20 weeks is feasible and effective for the preparation of a CCS model in the aged rhesus monkeys.

• 出版日期2016
• 单位广西医科大学