Novel Adociaquinone Derivatives from the Indonesian Sponge Xestospongia sp.

作者：He Fei; Mai Linh H; Longeon Arlette; Copp Brent R; Loaec Nadege; Bescond Amandine; Meijer Laurent; Bourguet Kondracki Marie Lise^*

来源：Marine Drugs, 2015, 13(5): 2617-2628.

DOI：10.3390/md13052617

• kinase inhibitor
• adociaquinone
• xestoadociaquinone
• 14-carboxy-xestoquinol sulfate
• xestoadociaminal
• Xestospongia sp

Seven new adociaquinone derivatives, xestoadociaquinones A (1a), B (1b), 14-carboxy-xestoquinol sulfate (2) and xestoadociaminals A-D (3a, 3c, 4a, 4c), together with seven known compounds (5-11) were isolated from an Indonesian marine sponge Xestospongia sp. Their structures were elucidated by extensive 1D and 2D NMR and mass spectrometric data. All the compounds were evaluated for their potential inhibitory activity against eight different protein kinases involved in cell proliferation, cancer, diabetes and neurodegenerative disorders as well as for their antioxidant and antibacterial activities.

• 出版日期2015-5