Angiopoietin-like protein 8/betatrophin correlates with hepatocellular lipid content independent of insulin resistance in non-alcoholic fatty liver disease patients

作者：Hong, Beverly S; Liu, Juan; Zheng, Jing; Ke, Weijian; Huang, Zhimin; Wan, Xuesi; He, Xiaoying; Xiao, Haipeng; Li, Yanbing^*

来源：Journal of Diabetes Investigation, 2018, 9(4): 952-958.

DOI：10.1111/jdi.12792

• Angiopoietin-like protein 8
• Hepatocellular lipid content
• Non-alcoholic fatty liver disease

Aims/IntroductionTo explore angiopoietin-like protein 8 (ANGPTL-8) levels, and its association with hepatocellular lipid content (HCL) and insulin resistance in patients with different extents of non-alcoholic fatty liver disease (NAFLD).
Materials and MethodsIn 48 adults were recruited, of which 12 had no NAFLD (HCL < 5.5%; group 1), 18 had mild NAFLD (5.5% HCL < 10.0%; group 2) and 18 had moderate-to-severe NAFLD (HCL 10.0%; group 3). The peripheral insulin sensitivity of all participants was monitored by a hyperinsulinemic-euglycemic clamp (M value), as well as the magnetic resonance image of HCL. Serum ANGPTL-8, blood glucose levels and lipid profiles were also recorded in the study.
ResultsGroup 3 had a worse metabolic profile, and had the highest ANGPTL-8 level (1,129 351 pg/mL vs 742 +/- 252 pg/mL, 765 +/- 301 pg/mL, P = 0.001) compared with those in group 1 and group 2. In all metabolic profiles, HCL positively correlated the strongest with ANGPTL-8 (r = 0.436, P = 0.042). Multivariate stepwise linear regression analysis showed ANGPTL-8 and alanine aminotransferase were independent determinants of HCL (P = 0.002, P < 0.001, respectively), and these two indexes explained 67.4% of the variation of HCL (P < 0.001).
ConclusionsANGPTL-8 was positively correlated with hepatocellular lipid content independent of obesity and insulin resistance, indicating that ANGPTL-8 might be a new and important important predictor of the severity of NAFLD.

• 出版日期2018-7
• 单位中山大学