Aerobic oxidation of secondary benzylic alcohols and direct oxidative amidation of aryl aldehydes promoted by sodium hydride

作者：Wang, Xinbo; Wang, David Zhigang^*

来源：Tetrahedron, 2011, 67(19): 3406-3411.

DOI：10.1016/j.tet.2011.03.052

• Sodium hydride
• Aerobic oxidation
• Oxidative amidation
• Benzylic alcohol
• Sodium hydrogen peroxide

We reported herein new reactivities and possible mechanistic implications of a simplest oxidant (NaH/air) uncovered on a broad range of useful transformations, including aerobic alcohol oxidations, allylic alcohol isomerizations and oxidations, cyclopropyl alcohol fragmentations, and direct aryl aldehyde oxidative amidations. These readily implementable transition-metal-free processes feature exceptional material accessibility, operational simplicity, and environmental compatibility, and add new dimensions to its synthetic utilities that are fairly robust yet had not previously been fully realized and systematically explored.

• 出版日期2011-5-13
• 单位北京大学深圳研究生院