A revisit to cockroach allergens

作者：Sookrung Nitat; Chaicumpa Wanpen^*

来源：Asian Pacific Journal of Allergy and Immunology, 2010, 28(2-3): 95-106.

• Cockroach
• Periplaneta americana
• Blattella germanica
• cockroach allergy
• cockroach allergens
• Per a 1
• ariginine kinase
• proteases
• atopy
• allergic rhinitis
• atopic asthma
• airway remodeling
• airway hyperresposiveness (AHR)
• IgE
• Fc(epsilon)RI
• Fc(epsilon)RII
• Th2
• Th17
• Th9
• Th25
• IL-17
• IL-9
• protease activated receptors (PARs)
• cockroach avoidance
• cockroach allergen detection
• cockroach allergen quantification
• G-protein couple receptor

Among cockroaches (CR) that live in people's homes, two species, i.e., German CR (Blattella germanica) and American CR (Periplaneta americana) predominate in temperate and tropical areas, respectively. CR is an important source of inhalant indoor allergens that sensitize atopic subjects to (localized) type I hypersensitivity or atopy including allergic rhinitis and atopic asthma. In Thailand the predominant CR species is P. americana. CR allergens are found throughout CR infested houses; the number found in kitchens correlates with the degree of CR infestation while sensitization and reactivation of the allergic morbidity are likely to occur in the living room and bedroom. Levels of the CR allergens in homes of CR allergic Thais, measured by using locally made quantification test kits, revealed that the highest levels occur in dust samples collected from the wooden houses of urban slums and in the cool and dry season. CR allergens are proteins that may be derived from any anatomical part of the insect at any developmental stage. The allergens may be also from CR secretions, excretions, body washes or frass. The proteins may be the insect structural proteins, enzymes or hormones. They may exist as dimers/multimers and/or in different isoforms. Exposure to CR allergens in infancy leads to allergic morbidity later in life. Clinical symptoms of CR allergy are usually more severe and prolonged than those caused by other indoor allergens. The mechanisms of acute and chronic airway inflammation and airway hyper-responsiveness (AHR) have been addressed including specific IgE- and non-IgE-mediated mechanisms, i.e., role of protease-activated receptor-2 (PAR2). Participation of various allergen activated-CD4(+) T cells of different sublineages, i.e., Th2, Th17, Th22, Th9, Th25, Tregs/Th3 as well as invariant NKT cells, in asthma pathogenesis have been mentioned. The diagnosis of CR allergy and the allergy intervention by CR population control are also discussed. (Asian Pac J Allergy Immunol 2010;28:95-106)

• 出版日期2010-9