Comparison of IV and IM Formulations of Synthetic ACTH for ACTH Stimulation Tests in Healthy Dogs

作者：Cohen T A^*; Feldman E C

来源：Journal of Veterinary Internal Medicine, 2012, 26(2): 412-414.

DOI：10.1111/j.1939-1676.2011.00882.x

• Adrenal gland
• Endocrinology
• Hyperadrenocorticism

Background: Two commercially available forms of synthetic ACTH are used to diagnose and monitor hyper-and hypoadrenocorticism in dogs.
Objective: To compare the biologic activity of the liquid and lyophilized forms of cosyntropin.
Animals: Eighteen privately owned healthy dogs were included.
Methods: Dogs were assigned to one of 2 groups of 9 dogs each. Group 1 dogs were tested with the lyophilized product first and the liquid solution 30-60 days later. The Group 2 dogs were tested with the liquid solution first and the lyophilized drug 30-60 days later. For the ACTH stimulation tests, serum samples were collected before and 1 hour after IM administration of 0.25 mg reconstituted lyophilized product or 1 hour after IV administration of 0.25 mg of liquid solution. Cortisol concentrations of all serum samples were measured by use of a commercial cortisol radioimmunoassay.
Results: Serum cortisol concentrations before and after ACTH stimulation did not differ significantly between groups (P =.57). In addition, no individual dog had as much as a 20% difference in serum cortisol concentrations after administration of either ACTH formulation.
Conclusions and Clinical Importance: Given the lack of significant differences of the ACTH stimulation test results, the lyophilized and liquid solution products can be used interchangeably.

• 出版日期2012-4