An environmentally benign and efficient synthesis of substituted benzothiazole-2-thiols, benzoxazole-2-thiols, and benzimidazoline-2-thiones in water

作者：Liu, Xing; Liu, Min; Xu, Wan; Zeng, Meng-Tian; Zhu, Hui; Chang, Cai-Zhu; Dong, Zhi-Bing^*

来源：Green Chemistry, 2017, 19(23): 5591-5598.

DOI：10.1039/c7gc02311a

• CATALYZED TANDEM REACTION
• CARBON-DISULFIDE
• DERIVATIVES
• 2-AMINOBENZOTHIAZOLES
• INHIBITION
• 2-MERCAPTOBENZOXAZOLE
• CYCLOOXYGENASE
• ANTAGONISTS
• THIOUREAS
• ANALOGS

An efficient and practical method for the one-step synthesis of benzothiazole-2-thiols, benzoxazole-2thiols and benzimidazoline-2-thiones by cyclization of 2-aminothiophenols, 2-aminophenols, and 1,2-phenylenediamines with tetramethylthiuram disulfide (TMTD) in water was described. The features of this method include metal/ligand-free, excellent yield, short reaction time and broad substrate scope. The method provides a facile and convenient preparation of some potentially biologically active compounds.

• 出版日期2017-11-28
• 单位武汉工程大学