A simple and environmentally benign synthesis of polypyridine-polycarboxylic acids

作者：Kelly Niamh R; Goetz Sandrine; Hawes Chris S; Kruger Paul E^*

来源：Tetrahedron Letters, 2011, 52(9): 995-998.

DOI：10.1016/j.tetlet.2010.12.074

• Environmentally benign
• Polypyridine-polycarboxylate
• Oxidation
• Solvothermal
• 2,2 '-Bipyridines

An oxidation method using dilute nitric acid solutions under solvothermal conditions has been developed to synthesise a series of polypyridine-polycarboxylic acids. It has been successfully applied to a range of methyl substituted polypyridines including symmetrical and asymmetrical 2,2'-bipyridines; 2,2':6',2 ''-terpyridines and; 2,2':6',2 '':6 '',2'''-tetra-pyridines and yields crystalline polypyridine-polycarboxylic acids in a single step. Simple product recovery through filtration yields a recyclable filtrate. More forcing conditions led to demethylation of the polypyridine ligand most probably via decarboxylation. This simple approach avoids potentially harmful metal-based oxidants and negates any issues associated with the disposal of their resultant (hazardous) waste.

• 出版日期2011-3-2