Urea as mild and efficient additive for palladium catalyzed Sonogashira cross coupling reaction

作者：Sarmah Manashi; Dewan Anindita; Thakur Ashim J; Bora Utpal

来源：Tetrahedron Letters, 2016, 57(8): 914-916.

DOI：10.1016/j.tetlet.2016.01.046

• Sonogashira coupling
• Aryl halides
• Pd(OAc)(2)
• Urea
• EtOH

catalytic system based on Pd(OAc)(2)/urea has been developed for Sonogashira cross coupling of aryl halides with terminal alkynes at room temperature. This catalytic system effectively promotes Sonogashira coupling of both aryl iodides and aryl bromides to give polyfunctional alkynes under copper and amine free conditions. The catalytic system is readily accessible, inexpensive and highly flexible for both aromatic and aliphatic alkynes.

• 出版日期2016-2-24