Dosage changes in patients with long-term botulinum toxin use for laryngeal dystonia

作者：Birkent Hakan^*; Maronian Nicole; Waugh Patricia; Merati Albert L; Perkel David; Hillel Allen D

来源：Otolaryngology - Head and Neck Surgery, 2009, 140(1): 43-47.

DOI：10.1016/j.otohns.2008.10.033

OBJECTIVE: To investigate the dosage consistency of botulinum toxin injections in patients with long-term treatment for laryngeal dystonia.
STUDY DESIGN: Chart review.
SUBJECTS AND METHODS: Patients with laryngeal dystonia who had received at least 20 injections to the thyroarytenoid muscle were selected. Change Of botulinum toxin dose, patient-reported effective weeks, and intervals between injections were investigated data from the first five injections were excluded to eliminate initial dose titration.
RESULTS: Fifty-five patients with an average follow-up Of 12.5 years were identified, Mean dose of botulinum toxin was 2.37 /- 1.6 U at the sixth injection; there was a decrease in mean dose over time, which became statistically significant at the 13th injection with a mean dose of 2.02 /- 1.16 U. Mean duration of good effect and treatment intervals showed no significant change over time.
CONCLUSION: Botulinum toxin close needed for it constant response in treatment of laryngeal dystonia decreases over time, without any accompanying change in effective weeks and intervals.

• 出版日期2009-1
• 单位中国人民解放军军事医学科学院