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摘要
A facile synthetic method to chromenones and thiochromenones has been developed using a one-pot Friedel-Crafts acylation of alkynes with suitably substituted benzoyl chlorides. This unified approach to (thio)-chromenones is readily applicable to aryl- and alkylalkynes where the stereochemically well-defined beta-chlorovinyl ketone intermediates undergo distinctively different cydlization pathways. The ready availability of both starting materials, alkynes and benzoyl chlorides, coupled with the experimental simplicity makes the current synthetic method to (thio)chromenones fast, efficient, and practical.
- 出版日期2017-1-20
