A silica fiber coated with a ZnO-graphene oxide nanocomposite with high specific surface for use in solid phase microextraction of the antiepileptic drugs diazepam and oxazepam

作者：Alizadeh Reza^*; Salami Maryam; Seidi Shahram

来源：Microchimica Acta, 2018, 185(6): UNSP 312.

DOI：10.1007/s00604-018-2850-2

• Nanosorbent
• Nanorods
• Nanosheets
• Urine sample
• Response surface methodology
• Experimental design

A novel ZnO-graphene oxide nanocomposite was prepared and is shown to be a viable coating on fused silica fibers for use in solid phase microextraction (SPME) of diazepam and oxazepam from urine, this followed by thermal desorption and gas chromatographic quantitation using a flame ionization detector. A central composite design was used to optimize extraction time, salt percentage, sample pH and desorption time. Limits of detection are 0.5 mu g.L-1 for diazepam and 1.0 mu g.L-1 for oxazepam. Repeatability and reproducibility for one fiber (n = 4), expressed as the relative standard deviation at a concentration of 50 mu g.L-1, are 8.3 and 11.3% for diazepam, and 6.7 and 10.1% for oxazepam. The fiber-to-fiber reproducibility is < 17.6%. The calibration plots are linear in the 5.0-1000 mu g.L-1 diazepam concentration range, and from 1.0-1000 mu g.L-1 in case of oxazepam. The fiber for SPME has high chemical and thermal stability (even at 280 degrees C) after 50 extractions, and does not suffer from a reduction in the sorption capacity.

• 出版日期2018-6