Non-curative gastric resection for patients with stage 4 gastric cancer-a single center experience and current review of literature

作者：Dittmar Yves^*; Rauchfuss Falk; Goetz Max; Jandt Karin; Scheuerlein Hubert; Heise Michael; Settmacher Utz

来源：Langenbeck's Archives of Surgery, 2012, 397(5): 745-753.

DOI：10.1007/s00423-012-0902-3

• Non-curative gastric resection
• Chemotherapy
• Survival
• Gastric cancer

The majority of patients with gastric cancer present with an advanced stage and, therefore, may not be eligible for curative treatment. The role of non-curative gastric resection in situations other than emergency treatment for life threatening tumor-related complications is still under discussion. %26lt;br%26gt;Data from 290 consecutive patients with advanced gastric cancer who were treated in our hospital were analyzed. A total of 48 patients underwent primary non-curative gastric resection. %26lt;br%26gt;The overall survival in the non-curatively resected group was 15 months and 6 months for non-resected patients, respectively ( %26lt; 0.001). The incidence of tumor-related complications which required intervention was 63% in non-resected patients as compared to 12% in patients who underwent primary non-curative resection. Younger age, less than three tumor locations, and chemotherapy have been identified as prognostic factors for improved survival by univariate analysis. D3 lymph node involvement and chemotherapy were independent prognostic factors in the multivariate analysis. Peritoneal carcinosis did not significantly influence survival in resected patients. Non-curative resection in combination with chemotherapy resulted in longer overall survival than resection alone. %26lt;br%26gt;Primary non-curative gastric resection can reduce the incidence of severe tumor-related complications and can prolong overall survival in selected subgroups. In particular, younger patients with no more than two tumor locations should be considered for this procedure.

• 出版日期2012-6