A Phase Ib Study of the Dual PI3K/mTOR Inhibitor Dactolisib (BEZ235) Combined with Everolimus in Patients with Advanced Solid Malignancies

作者：Wise Draper Trisha M; Moorthy Ganesh; Salkeni Mohamad A; Karim Nagla Abdel; Thomas Hala Elnakat; Mercer Carol A; Beg M Shalaan; O'Gara Sue; Olowokure Olugbenga; Fathallah Hassana; Kozma Sara C; Thomas George; Rixe Olivier; Desai Pankaj^*; Morris John C^*

来源：Targeted Oncology, 2017, 12(3): 323-332.

DOI：10.1007/s11523-017-0482-9

The combination of everolimus and the imidazoquinoline derivative, BEZ235 (dactolisib), a dual PI3K/mTOR inhibitor, demonstrated synergy in a preclinical model.
To establish clinical feasibility, a phase Ib dose-escalation trial investigating safety and pharmacokinetics of this combination in patients with advanced tumors was performed.
BEZ235 was orally administered daily in escalating doses of 200, 400, and 800 mg along with everolimus at 2.5 mg daily in 28-day cycles. Nineteen patients were enrolled. Adverse events and tumor responses were evaluated using CTCAE v4.0 and RECIST 1.1, respectively. Pharmacokinetic analyses were performed.
Common toxicities observed included fatigue, diarrhea, nausea, mucositis, and elevated liver enzymes. No confirmed responses were observed. BEZ235 pharmacokinetics exhibited dose-proportional increases in C-max and AUC(0-24) over the three doses, with high inter-individual variability. Non-compartmental and population pharmacokinetic-based simulations indicated significant increases in everolimus C-max and AUC(0-24) on day 28 and decreased clearance to 13.41 L/hr.
The combination of BEZ235 and everolimus demonstrated limited efficacy and tolerance. BEZ235 systemic exposure increased in a dose-proportional manner while oral bioavailability was quite low, which may be related to gastrointestinal-specific toxicity. The changes in steady-state pharmacokinetics of everolimus with BEZ235 highlight potential drug-drug interactions when these two drugs are administered together.
Clinicaltrials.gov: NCT01508104.

• 出版日期2017-6