A Perinatal Palatable High-Fat Diet Increases Food Intake and Promotes Hypercholesterolemia in Adult Rats

作者：Souza Oliveira Tchana Weyll; Leandro Carol Gois^*; de Jesus Deiro Tereza Cristina Bomfim; Perez Gabriela dos Santos; Silva Darlene da Franca; Druzian Janice Izabel; Couto Ricardo David; Barreto Medeiros Jairza Maria

来源：Lipids, 2011, 46(11): 1071-1074.

DOI：10.1007/s11745-011-3604-7

• Hyperlipidic diet
• Cholesterolemia
• Rats
• Developmental plasticity
• Critical period of development

The main goal of the present study was to evaluate the long-term effects of a perinatal palatable high-fat diet on the food intake and cholesterol profile of adult rats. Male Wistar rats (aged 22 days) were divided into two groups according to their mother's diet during gestation and lactation (C (p), n = 10; pups from control mothers; and HL(p) n = 10; pups from mothers fed a palatable high-fat diet). At the 76th day, pups were housed individually for 14 days, and daily food consumption was determined during a period of 6 days. Blood from 100-day-old rats was sampled by cardiac puncture. Fasting (12 h) serum glucose, total cholesterol, LDL-C, HDL-C, triglycerides (TG), and VLDL-C levels were determined. The measurement of food intake was higher in the animals submitted to a hyperlipidic diet during the perinatal period. Serum total cholesterol, LDL-C, HDL-C, TG, VLDL-C and glycemia were increased in the HL(p) group compared to the control group. Our findings show that an early life environment with a high-fat diet can contribute to metabolic disease in later life.

• 出版日期2011-11