Activation of the alternative complement pathway by mannose-binding lectin via a C2-bypass pathway

作者：Tateishi Koichiro; Matsushita Misao^*

来源：Microbiology and Immunology, 2011, 55(11): 817-821.

DOI：10.1111/j.1348-0421.2011.00378.x

• alternative pathway
• complement
• mannose-binding lectin

MBL is a serum lectin that activates the lectin pathway of the complement system. MBL forms complexes with three types of MASPs. Upon binding to Salmonella serogroup C-specific oligosaccharide, MBL activates the alternative pathway via a C2-bypass pathway without involving MASP-2, C2 or C4. We demonstrate that mannan-bound MBL activates the alternative pathway via a C2-bypass pathway that requires MASP-2 and C4. Thus, depending on the ligands to which MBL binds, there may be two distinct MBL-mediated C2-bypass pathways.

• 出版日期2011-11