Association Between the Location of Diverticular Disease and the Irritable Bowel Syndrome: A Multicenter Study in Japan

作者：Yamada Eiji; Inamori Masahiko; Uchida Eri; Tanida Emiko; Izumi Motoyoshi; Takeshita Kimiya; Fujii Tetsuro; Komatsu Kazuto; Hamanaka Jun; Maeda Shin; Kanesaki Akira; Matsuhashi Nobuyuki; Nakajima Atsushi^*

来源：American Journal of Gastroenterology, 2014, 109(12): 1900-1905.

DOI：10.1038/ajg.2014.323

OBJECTIVES: No previous reports have shown an association between location of diverticular disease (DD) and the irritable bowel syndrome (IBS). %26lt;br%26gt;METHODS: We included 1,009 consecutive patients undergoing total colonoscopy in seven centers in Japan from June 2013 to September 2013. IBS was diagnosed using Rome III criteria, and diverticulosis was diagnosed by colonoscopy with transparent soft-short-hood. Left-sided colon was defi ned as sigmoid colon, descending colon, and rectum. Right-sided colon was defi ned as cecum, ascending colon, and transverse colon. We divided the patients into IBS and non-IBS groups and compared characteristics. %26lt;br%26gt;RESULTS: Patient characteristics included mean age, 64.2 +/- 12.9 years and male: female ratio, 1.62: 1. Rightsided DD was identifi ed in 21.6% of subjects. Left-sided and bilateral DD was identifi ed in 6.6 and 12.0% of subjects, respectively. IBS was observed in 7.5% of subjects. Multiple logistic regression analysis showed left-sided DD (odds ratio, 3.1; 95% confi dence interval (CI): 1.4-7.1; P = 0.0060) and bilateral DD (odds ratio, 2.6; 95% CI, 1.3-5.2; P = 0.0070) were independent risk factors for IBS. Right-sided DD was not a risk factor for IBS. %26lt;br%26gt;CONCLUSIONS: Our data showed that the presence of left-sided and bilateral DD, but not right-sided disease, was associated with a higher risk of IBS, indicating that differences in pathological factors caused by the location of the DD are important in the development of IBS. Clarifying the specifi c changes associated with left-sided DD could provide a better understanding of the pathogenic mechanisms of IBS

• 出版日期2014-12