Anomalous PiB enhancement in the Superior Sagittal and Transverse Venous Sinuses

作者：Raymond Scott B; Cohen Ann D; Becker Carl; Price Julie; Klunk William E^*

来源：Alzheimer Disease and Associated Disorders, 2012, 26(2): 186-190.

DOI：10.1097/WAD.0b013e31822de18c

• amyloid-beta
• PET imaging
• Alzheimer disease
• PIB
• FDG

Pittsburgh compound-B (PiB), an amyloid-binding positron emission tomography (PET) tracer, is widely used for imaging amyloid-beta in those with and at risk for Alzheimer disease. Here, we report on an otherwise normal 68-year-old female with abnormally high and very focal PiB retention. Coregistered T1-weighted magnetic resonance imaging and dynamic 2-fluoro-2-deoxy-D-glucose (FDG) images confirmed that the focal PiB enhancement was in the superior sagittal and transverse sinuses, outside of the adjacent cortex. Flow through the venous vasculature was normal as assessed by dynamic FDG PET imaging. These features supported the conclusion that PiB retention was not simply due to a hemodynamic abnormality, but may have represented PiB binding to fibrillar deposits of a beta-sheet protein (ie, amyloid), whose nature is currently unclear.

• 出版日期2012-6