A New Method for Thiomethylation of Hydroxy-1,4-naphthoquinones with N-Acetyl-L-cysteine; First Synthesis of Fibrostatins B, C, and D

作者：Sabutskii Yuri E; Polonik Sergey G^*; Denisenko Vladimir A; Dmitrenok Pavel S

来源：Synthesis (Germany), 2014, 46(20): 2763-2770.

DOI：10.1055/s-0034-1378522

• quinones
• thiols
• natural products
• fibrostatins
• amino acids

A series of N-acetyl-S-[(3-hydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)methyl]-L-cysteine conjugates were obtained in good yields by acid-catalyzed condensation of substituted 2-hydroxy-1,4-naphthoquinones with N-acetyl-L-cysteine and paraformaldehyde. Based on this reaction, a first synthesis of fibrostatins B, C, and D was developed.

• 出版日期2014-10