A novel Prins reaction for the synthesis of hexahydro-8, 8-dimethyl-1H-isochromen-7-ol derivatives

作者：Reddy B V Subba^*; Anjum S Rehana; Reddy G Madhusudhan; Sridhar B

来源：Tetrahedron Letters, 2014, 55(36): 5011-5013.

DOI：10.1016/j.tetlet.2014.07.072

• Bronsted acid catalysis
• Bicycles
• Prins cyclization
• Hexahydro-1H-isochromen-7-ols

Various aldehydes undergo smooth coupling with 5-(hydroxymethyl)-4,6,6-trimethylcyclohex-3-enol in the presence of p-TSA at ambient temperature to afford a novel series of hexahydro-8,8-dimethyl-1H-isochromen-7-ol derivatives in good yields with high selectivity. This is the first report on the synthesis of isochromen-7-ol derivatives via the Prins reaction.

• 出版日期2014-9-3