Doxorubicin-Loaded Zein in Situ Gel for Interstitial Chemotherapy

作者：Cao, Xiaoying; Geng, Jianning; Su, Suwen; Zhang, Linan; Xu, Qian; Zhang, Li; Xie, Yinghua; Wu, Shaomei; Sun, Yongjun; Gao, Zibin^*

来源：CHEMICAL & PHARMACEUTICAL BULLETIN, 2012, 60(10): 1227-1233.

DOI：10.1248/cpb.c12-00270

• interstitial chemotherapy
• in situ gel
• laser scanning confocal microscopy
• microdialysis
• local pharmacokinetic mathematical model

A novel drug delivery system of doxorubicin (DOX)-loaded Zein in situ gel for interstitial chemotherapy was investigated in this study. The possible mechanisms of drug release were described according to morphological analysis by optical microscopy and scanning electronic microscope (SEM). In vitro and in vivo anti-tumor activity studies showed that DOX-loaded Zein in situ gel was superior to DOX solution. Local pharmacokinetics in tumor tissue was studied by quantitative analysis with confocal laser scanning microscopy (CLSM) combined with microdialysis technology. A pharmacokinetics mathematical model of DOX-loaded Zein in situ gel in tumors was then built.

• 出版日期2012-10
• 单位河北医科大学; 河北科技大学