科研之友
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摘要
Mapping the human brain is one of the great scientific challenges of the 21st century. Brain network analysis is an effective technique based on graph theory that is widely used to investigate network patterns in the human brain. Currently, mapping an individual brain network using a single image has been a hotspot in the field of brain science; techniques, such as the Kullback-Leibler (KL) method, have applications in structural Magnetic Resonance (MR) imaging. However, maintaining an image's intensity, shape, texture and gradient information during feature extraction is very challenging. In this study, we propose a novel method for individual-level network construction based on the high-resolution Brainnetome Atlas, which shows 246 brain regions. Principal components (PCs) were obtained for each brain region using principal component analysis (PCA) for feature extraction. Individual brain networks were followed and used to construct the PC similarity measurement based on the mutual information (MI) method. To evaluate the robustness of the proposed method, three independent experiments were carried out. In the first, 34 healthy subjects underwent two Carbon 11-labeled Pittsburgh compound B Positron emission tomography (11C-PiB PET) scans; in the second, 32 healthy subjects underwent two structural MRI scans; and in the last, 10 Alzheimer's disease (AD) subjects and 10Healthy Control (HC) subjects underwent 11C-PiB PET scans. For each subject, network metrics including clustering coefficient, path length, small-world coefficient, efficiency and node betweenness centrality were calculated. The results suggested that both the individual PET and structural MRI networks exhibited a good small-word property, and the variances within subjects was also quite small in all metrics, The average value of Coefficient of variation (CV) map was 0.33 and 0.32 for PiB PET and MR images respectively, and intra-class correlation coefficients (ICC) range from approximately 0.4 to 0.7, indicating that the new method was well adapted to the subjects. The results of intra-class correlation coefficients from the test-retest experiment were consistent with previous research employing KL divergence, but with low computational complexity. Further, differences between AD subjects and HC subjects can be observed in network metrics. The method proposed herein provides a new perspective for investigating individual brain connectivity; it would enable neuroscientists to further understand the functions of the human brain.
- 出版日期2017-12
- 单位上海大学
