Association of circulating ANGPTL 3, 4, and 8 levels with medical status in a population undergoing routine medical checkups: A cross-sectional study

作者：Morinaga Jun^*; Zhao Jiabin; Endo Motoyoshi; Kadomatsu Tsuyoshi; Miyata Keishi; Sugizaki Taichi; Okadome Yusuke; Tian Zhe; Horiguchi Haruki; Miyashita Kazuya; Maruyama Nobuhiro; Mukoyama Masashi; Oike Yuichi^*

来源：PLos One, 2018, 13(3): e0193731.

DOI：10.1371/journal.pone.0193731

Purpose
Angiopoietin-like proteins (ANGPTLs) 3, 4, and 8 reportedly contribute to progression of metabolic disease, a risk factor for cardiovascular disease (CVD). The purpose of this study was to investigate whether circulating ANGPTL levels are associated with CVD risk after adjustment for potential confounding factors.
Methods
We conducted a single center, cross-sectional study of 988 Japanese subjects undergoing routine health checks. Serum ANGPTL3, 4, and 8 levels were measured using an enzyme-linked immunosorbent assay. Using multiple regression analysis we evaluated potential association of circulating ANGPTL3, 4, and 8 levels with general medical status including age, sex, smoking, drinking, obesity, hypertension, impaired glycometabolism, dyslipidemia, hyperuricemia, hepatic impairment, chronic kidney disease, anemia, cardiac abnormality, and inflammation.
Results
Circulating ANGPTL3 levels were relatively high in health-related categories of hepatic impairment and inflammation. Circulating ANGPTL4 levels were also significantly high in impaired glycometabolism or hepatic impairment but decreased in inflammation. Finally, increased ANGPTL8 levels were observed in obesity, impaired glycometabolism and dyslipidemia. Particularly, increased levels of circulating ANGPTL8 were positively correlated with circulating triglycerides and LDL-cholesterol levels and inversely correlated with circulating HDL-cholesterol levels.
Conclusions
Circulating ANGPTL3, 4, and 8 levels reflect some risk factors for CVD development.

• 出版日期2018-3-14