Dietary intake and childhood leukemia: The Diet and Acute Lymphoblastic Leukemia Treatment (DALLT) cohort study

作者：Ladas, Elena J.^*; Orjuela, Manuela; Stevenson, Kristen; Cole, Peter D.; Lin, Meiko; Athale, Uma H.; Clavell, Luis A.; Leclerc, Jean-Marie; Michon, Bruno; Schorin, Marshall A.; Welch, Jennifer Greene; Asselin, Barbara L.; Sallan, Stephen E.; Silverman, Lewis B.; Kelly, Kara M.

来源：Nutrition, 2016, 32(10): 1103-1109.

DOI：10.1016/j.nut.2016.03.014

• Dietary intake
• Nutritional status
• Micronutrient intake: macronutrient intake
• Obesity
• Pediatric oncology
• Acute lymphoblastic leukemia

Objective: Children with acute lymphoblastic leukemia (ALL) are at elevated risk for nutrition related morbidity both during and after therapy. We present the demographic characteristics and nutrient intake at study entry of a prospective cohort in which evaluating dietary intake in children diagnosed with ALL was investigated.
Methods: Dietary intake data were collected for participants enrolled on the Dana-Farber Cancer Institute ALL Consortium Protocol. Dietary intake was assessed with a food frequency questionnaire and was compared with the dietary reference intake by ALL risk group (standard and high risk).
Results: Dietary intake data were collected from 81% of participants (n = 640). We found that 27% of participants were overweight/obese. Intake of total calories and other nutrients exceeded the dietary reference intake in up to 79% of children. This was evident in both risk groups and was pronounced among younger children. For micronutrients, dietary intake of calcium, vitamin D (females only), and zinc differed significantly between patients with standard-risk and those with high-risk ALL.
Conclusions: This study was successful in collecting dietary intake data at the time of cancer diagnosis in a multicenter setting in a pediatric population at high-risk for nutrition-related morbidity. We identified "at-risk" dietary intakes, which vary by sex and ALL risk group; such patients may benefit from future dietary interventions.

• 出版日期2016-10
• 单位南宁师范大学