Association of cytotoxic T-lymphocyte antigen 4 genetic polymorphism, hepatitis C viral infection and B-cell non-Hodgkin lymphoma: an Egyptian study

作者：Khorshied Mervat Mamdooh^*; Gouda Heba Mahmoud; Khorshid Ola M Reda

来源：Leukemia and Lymphoma, 2014, 55(5): 1061-1066.

DOI：10.3109/10428194.2013.820294

• CTLA-4
• genetic polymorphism
• HCV
• B-NHL
• Egypt

Genetic and environmental factors are involved in the pathogenesis of non-Hodgkin lymphoma (NHL). The present study aimed to investigate the association between cytotoxic T-lymphocyte antigen 4 (CTLA-4) genetic polymorphism, hepatitis C virus (HCV) infection and B-cell NHL risk in Egypt. Genotyping of CTLA-4 single nucleotide polymorphisms (SNPs) was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay for 181 adult patients with B-NHL and 200 controls. Our study revealed that CTLA-4+49 A/G polymorphism conferred increased risk of B-NHL (odds ratio [OR] = 1.7, 95% confidence interval [CI] = 1.36-2.565). The prevalence of HCV infection in individuals harboring the mutant genotype +49 A/G and associated with increased risk of B-NHL (OR = 2.79, 95% CI = 1.24-6.93 for +49 A/G and OR = 3.9, 95% CI = 1.01-15.98 for -318 C/T). In conclusion, some SNPs of CTLA-4 are genetic risk factors for B-NHL. Moreover, this study identifi ed an association of CTLA-4+49 A/G and -318 C/T promoter polymorphisms with HCV infection.

• 出版日期2014-5