Development of a novel in vitro onychomycosis model for the evaluation of topical antifungal activity

作者：Sleven Reindert; Lanckacker Ellen; Boulet Gaelle; Delputte Peter; Maes Louis; Cos Paul^*

来源：Journal of Microbiological Methods, 2015, 112: 73-75.

DOI：10.1016/j.mimet.2015.03.009

• Onychomycosis
• Topical antifungals
• Drug evaluation

A novel in vitro onychomycosis model was developed to easily predict the topical activity potential of novel antifungal drugs. The model encompasses drug activity and diffusion through bovine hoof slices in a single experimental set-up. Results correspond well with the antifungal susceptibility assay and Franz cell diffusion test.

• 出版日期2015-5