Antimony(III) halide compounds of thioureas: Structures and biological activity

作者：Han A; Ozturk I I^*; Banti C N; Kourkoumelis N; Manoli M; Tasiopoulos A J; Owczarzak A M; Kubicki M; Hadjikakou S K

来源：Polyhedron, 2014, 79: 151-160.

DOI：10.1016/j.poly.2014.05.014

• Antimony(III) halide
• Thioureas
• Crystal structures
• Cytotwdcity
• PCA

Antimony(III) halide compounds (SbX3, X = Cl and Br) of thioureas; tetramethylthiourea (TMTU), N,N%26apos;-diethylthiourea (DETU) and 1,3-diisopropy1-2-thiourea (DIPTU) of formulae {[SbCl3(TMTU)](n)} (1), {[SbBr3(TMTU)](n)} (2), {[mer-SbCl3(DIPTU)(3))] [fac-SbCl3(DIPTU)(3)] C6H6} (3) and {[SbBr2(DETU)(2)](+)center dot Br-}(n) (4) were synthesized. The complexes were characterized by their melting point, elemental analysis, FT-IR spectroscopy, FT-Raman spectroscopy, H-1 and C-13 NMR spectroscopy and Thermal Gravimetry-Differential Thermal Analysis (TG-DTA). The crystal and molecular structures of complexes 2-4 were determined with single crystal X-ray diffraction analysis. Compounds 1 and 2 are polymers with pseudo-trigonal bipyramidal (Psi-TBP) geometry in each monomeric unit. Compound 3 is a monomer with octahedral (Oh) geometry around Sb(III). Two different coordination modes of the ligands around antimony ions are observed in 3 forming two units. One with meridional orientation and the other with facial one. This complex is the first example of polymeric antimony(III) where two sequential antimony atoms have two different coordination modes. Two sulfur atoms and two bromines form a pseudotrigonal bipyramidal cationic [SbBr2(L)(2)](+) part with a bromide as counter anion in complex 4. Complexes 1-4 and their ligands were evaluated for their in vitro cytotoxic activity against human breast adenocarcinoma (MCF-7) and human cervical adenocarcinoma (HeLa) cells. Principal components analysis (PCA) was performed to discriminate the significant physicochemical molecular descriptors while regression analysis successfully relates the experimental inhibitory concentrations, (IC50) to the independent variables indexed by PCA.

• 出版日期2014-9-5