A highly enantioselective approach towards 2-substituted 3-bromopyrrolidines

作者:Chen Jie; Zhou Ling; Yeung Ying Yeung*
来源:Organic and Biomolecular Chemistry, 2012, 10(19): 3808-3811.
DOI:10.1039/c2ob25327e

摘要

A facile and highly enantioselective approach towards 2-substituted 3-bromopyrrolidines has been developed. The process involves an amino-thiocarbamate catalyzed bromoaminocyclization of 1,2-disubstituted olefinic amides. The pyrrolidine products could readily be converted into other useful building blocks including a dihydropyrrole and a 2-substituted pyrrolidine.

  • 出版日期2012