Bone-Targeted Cisplatin-Complexed Poly(gamma-benzyl-L-glutamate)-Poly(glutamic acid) Block Polymer Nanoparticles: An Electrochemical Approach

作者：de Miguel Laura^*; Cebrian Torrejon Gerardo; Caudron Eric; Arpinati Ludovica; Domenech Carbo Antonio; Ponchel Gilles

来源：ChemElectroChem, 2015, 2(5): 748-754.

DOI：10.1002/celc.201402400

• bone-targeted nanoparticles
• cancer
• cisplatin
• electrochemistry
• hydroxyapatite

The voltammetric response of different osteotropic multifunctional nanoparticles based on cisplatin-complexed poly(gamma-benzyl-L-glutamate)-poly(glutamic acid) block polymer (CDDP-PBLG-b-PGlu) copolymer, with or without poly(gamma-benzyl-L-glutamate)-poly(ethylene glycol) block polymer (PBLG-b-PEG), and having bone-targeting properties is studied at biologically relevant pH. Significant differences in the cisplatin-centered voltammetric signals allow monitoring of the association of cisplatin to nanoparticles as well as release kinetics from them, in agreement with atomic absorption spectroscopy data. Electrochemical studies reveal that the cisplatin association is significant only if the proportion of the PBLG-b-PGlu copolymer was greater than PBLG-b-PEG.

• 出版日期2015-5-13