科研之友
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摘要
Objective: We aimed to evaluate the possible contribution of alterations in serum copper and zinc levels to cardiac dysfunction in patients with dilated cardiomyopathy.
Material and Method: We determined blood copper and zinc levels in 16 patients with dilated cardiomyopathy awaiting heart transplantation and 16 control patients. Clinical severity of heart failure was assessed by New York Heart Associaton criteria and left ventricular ejection fraction by echocardiography.
Results: The mean serum copper level was significantly higher in the patient group than in control group (1.28 +/- 0.5 ppm and 0.81 +/- 0.21 ppm, respectively; p=0.0.1). Correlations between copper and heart failure severity and ejection fractions were not significant (r=0.303, p=0.30 and r=-0.33, p=0.21, respectively). There was no difference in zinc level between the patient and control group (0.85 +/- 0.82 ppm and 0.87 +/- 0.5 ppm, respectively; p=0.336). The correlation between zinc and heart failure severity was not significant (r=-0.23, p=0.4). A negative correlation was found between zinc and ejection fraction (r=-0.55, p=0.03).
Conclusion: The significantly increased copper level, the positive correlation between copper and the severity of heart failure and the negative correlation between ejection fraction (although without reaching statistical significance) suggest that it may have a role in cardiac dysfunction. The insignificant alteration of the zinc level compared to the controls may be reflecting the small size of the patient population. We suggest that further studies on larger patient populations are needed to define the role of these trace elements in the pathogenesis of dilated cardiomyopathy.
- 出版日期2010-8
