Fabrication of dicalcium phosphate dihydrate-coated beta-TCP granules and evaluation of their osteoconductivity using experimental rats

作者：Shariff Khairul Anuar; Tsuru Kanji^*; Ishikawa Kunio

来源：Materials Science and Engineering: C , 2017, 75: 1411-1419.

DOI：10.1016/j.msec.2017.03.004

• beta-Tricalcium phosphate granules
• Dicalcium phosphate dihydrate
• Acidic calcium phosphate solution
• Osteoconductivity
• Biocompatibility
• Coating

beta-Tricalcium phosphate (beta-TCP) has attracted much attention as an artificial bone substitute owing to its biocompatibility and osteoconductivity. In this study, osteoconductivity of beta-TCP bone substitute was enhanced without using growth factors or cells. Dicalcium phosphate dihydrate (DCPD), which is known to possess the highest solubility among calcium phosphates, was coated beta-TCP granules by exposing their surface with acidic calcium phosphate solution. The amount of coated DCPD was regulated by changing the reaction time between beta-TCP granules and acidic calcium phosphate solution. Histomorphometry analysis obtained from histological results revealed that the approximately 10 mol%DCPD-coated beta-TCP granules showed the largest new bone formation compared to DCPD-free beta-TCP granules, approximately 2.5 mol% DCPD-coated beta-TCP granules, or approximately 27 mol% DCPD-coated beta-TCP granules after 2 and 4 weeks of implantation. Based on this finding, we demonstrate that the osteoconductivity of beta-TCP granules could be improved by coating their surface with an appropriate amount of DCPD.

• 出版日期2017-6-1