Doxorubicin, DNA torsion, and chromatin dynamics

作者：Yang Fan; Teves Sheila S; Kemp Christopher J^*; Henikoff Steven

来源：Biochimica et Biophysica Acta-Reviews on Cancer, 2014, 1845(1): 84-89.

DOI：10.1016/j.bbcan.2013.12.002

• Doxorubicin
• Anthracycline
• Cancer
• DNA torsion
• Chromatin dynamics
• Chemotherapy

Doxorubicin is one of the most important anti-cancer chemotherapeutic drugs, being widely used for the treatment of solid tumors and acute leukemias. The action of doxorubicin and other anthracydine drugs has been intensively investigated during the last several decades, but the mechanisms that have been proposed for cell killing remain disparate and controversial. In this review, we examine the proposed models for doxorubicin action from the perspective of the chromatin landscape, which is altered in many types of cancer due to recurrent mutations in chromatin modifiers. We highlight recent evidence for effects of anthracyclines on DNA torsion and chromatin dynamics that may underlie basic mechanisms of doxorubicin-mediated cell death and suggest new therapeutic strategies for cancer treatment.

• 出版日期2014-1