Direct action of endocrine disrupting chemicals on human sperm

作者：Schiffer Christian; Mueller Astrid; Egeberg Dorte L; Alvarez Luis; Brenker Christoph; Rehfeld Anders; Frederiksen Hanne; Waeschle Benjamin; Kaupp U Benjamin; Balbach Melanie; Wachten Dagmar; Skakkebaek Niels E^*; Almstrup Kristian; Struenker Timo

来源：EMBO Reports, 2014, 15(7): 758-765.

DOI：10.15252/embr.201438869

• Ca2+ signalling
• CatSper
• endocrine disrupting chemical
• human sperm

Synthetic endocrine disrupting chemicals (EDCs), omnipresent in food, household, and personal care products, have been implicated in adverse trends in human reproduction, including infertility and increasing demand for assisted reproduction. Here, we study the action of 96 ubiquitous EDCs on human sperm. We show that structurally diverse EDCs activate the sperm-specific CatSper channel and, thereby, evoke an intracellular Ca2+ increase, a motility response, and acrosomal exocytosis. Moreover, EDCs desensitize sperm for physiological CatSper ligands and cooperate in low-dose mixtures to elevate Ca2+ levels in sperm. We conclude that EDCs interfere with various sperm functions and, thereby, might impair human fertilization.

• 出版日期2014-7