Analysis of co-spray-dried meloxicam-mannitol systems containing crystalline microcomposites

作者：Pomazi Anita; Ambrus Rita; Sipos Peter; Szabo Revesz Piroska^*

来源：Journal of Pharmaceutical and Biomedical Analysis, 2011, 56(2): 183-190.

DOI：10.1016/j.jpba.2011.05.008

• Dissolution rate
• Microparticles
• Spray-drying
• Poorly soluble drug
• Powder technology
• Morphology

The crystal size, form, wettability and rate of dissolution of a drug are factors limiting its nasal or pulmonary administration. The aim of this work was to achieve an ideal crystal habit, good wettability and the rapid release of meloxicam (MEL), a poorly water-soluble non-steroidal anti-inflammatory drug. The structures of MEL and the carrier-based systems were analysed by differential scanning calorimetry, X-ray diffractometry and Fourier transform infrared spectroscopy. The particle size and morphology were investigated by laser diffraction and SEM analyses. The novelty of this work was the use of a co-spray-drying technique, which resulted in mannitol-based crystalline microcomposites (1-6 mu m) containing MEL microcrystals (1-5 mu m). The particle size and form of the MEL microcrystals were adjusted by a top-down method. The presence of mannitol (with a MEL:mannitol mass ratio of 1:1) with additives ensured the homogeneous distribution of MEL in the microcomposites with good wettability and rapid release (100% MEL within 5 min).

• 出版日期2011-9-10