Analysis of the Smoke of Cigarettes Containing Salvia divinorum

作者：Krstenansky John L^*; Muzzio Miguel

来源：Journal of Analytical Toxicology, 2014, 38(7): 451-455.

DOI：10.1093/jat/bku054

Salvia divinorum is a hallucinogen sold over the internet in several forms. Perhaps the most common method of use is smoking the dried leaf material. The sole presumed active constituent, salvinorin A, is a selective kappa-opioid receptor agonist. Upon smoking of the dried leaf material, some of the salvinorin A is destroyed or converted to other materials, leaving in question the actual amount of salvinorin A delivered that leads to the psychotomimetic effect. On average, 133 mu g of salvinorin A was delivered in the smoke from an 830 mg per cigarette, which contained similar to 2.7 mg of salvinorin A. Hence, only similar to 5% of the salvinorin A available in the dried plant material was delivered in the smoke. Upon smoking, hydrolysis of salvinorin A to salvinorin B, an inactive and minor component of the leaf material, also occurs as evidenced by a higher delivered amount of salvinorin B vs salvinorin A (217 vs 133 mu g per cigarette). Since smoking is an effective means of achieving the hallucinogenic effect and salvinorin A is the presumed sole active ingredient in the plant, the estimated effective dose of salvinorin A by inhalation is %26lt;133 mu g per person. Considering the reported rapid metabolism of salvinorin A in vivo, the dose reaching the brain would be substantially less.

• 出版日期2014-9