Comparison of two combinations of opioid and non-opioid analgesics for acute periradicular abscess: a randomized clinical trial

作者：Santini Manuela Favarin^*; da Rosa Ricardo Abreu; Cardoso Ferreira Maria Beatriz; Fischer Maria Isabel; Souza Erick Miranda; Reis So Marcus Vinicius

来源：Journal of Applied Oral Science, 2017, 25(5): 551-558.

DOI：10.1590/1678-7757-2016-0407

• Analgesia
• Codeine
• Periapical abscess
• Tramadol
• Visual analog scale

Acute periradicular abscess is a condition characterized by the formation and propagation of pus in the periapical tissues and generally associated with debilitating pain. Objective: The aim of this study was to compare the overall analgesic effectiveness of two combinations of opioid and non-opioid analgesics for acute periradicular abscess. Material and Methods: This study included 26 patients who sought emergency care in a Brazilian dental school. The patients prescription of tramadol hydrochloride (37.5 mg) plus acetaminophen (500 mg) on the same schedule. Two factors were evaluated: (1) pain scores recorded by the patients in a pain diary 6, 12, 24, 48, and 72 h after treatment, using the Visual Analogue Scale; and (2) the occurrence of adverse effects. Results: In both groups, there was a reduction in pain scores over time. For the Co/Ac over time from time point 6 h (P<0.05). Comparing the pain at each time were effective in controlling pain caused by APA; however, the combination of Tr/Ac caused more adverse reactions as two patients had to stop using the medication. Conclusion: This study suggests that, considering both analgesic effective to control moderate to severe pain from acute periradicular abscesses.

• 出版日期2017-10