Detection of oxidized LDL using a carbon nanotube electrode

作者：Takeda Seiji; Hui Shu Ping; Fukuda Keisuke; Fuda Hirotoshi; Jin Shigeki; Sakurai Toshihiro; Ishii Atsushi; Mukasa Koichi; Sueoka Kazuhisa; Chiba Hitoshi^*

来源：Sensors and Actuators B: Chemical , 2012, 166: 833-836.

DOI：10.1016/j.snb.2012.02.064

• Sensor
• Lipid
• Lipoprotein
• Oxidation
• Nanotube

Oxidized low-density lipoproteins (LDLs) play a key role in cardiovascular disease development, but no convenient measurement method is available for them. Using a carbon nanotube (CNT) electrode, we measured oxidized LDL using amperometric detection. Treating SWCNT with a mixture of acids produced a CNT dispersion that yielded nanotube-based electrodes after deposition on a gold electrode and drying. Current was monitored in the nanotube electrode before and after adding LDL or oxidization of LDL Oxidized LDL changed the current more than 10 nA, although LDL addition induced no significant change. Our CNT electrode enables simple detection of oxidized LDL.

• 出版日期2012-5-20