Anti-inflammatory properties of rose oxide

作者：Nonato Fabiana Regina; Santana Danielle Gomes; de Melo Flavielle Martins; Leite dos Santos Gisele Graca; Brustolim Danielle; Camargo Enilton A; de Sousa Damiao P; Pereira Soares Milena Botelho; Villarreal Cristiane Flora^*

来源：International Immunopharmacology, 2012, 14(4): 779-784.

DOI：10.1016/j.intimp.2012.10.015

• Essential oils
• Monoterpenes
• Anti-inflammatory
• Cytokines

Rose-oxide is a fragrance found in roses and rose oil. There are no reports about the pharmacological activity of this molecule. The present study was undertaken to evaluate whether rose-oxide (RO) has anti-inflammatory properties and to investigate possible mechanisms involved with its effects. The anti-inflammatory activity of RO was first suggested by the formalin test in mice, an inflammatory pain model, because intraperitoneal (i.p.) administration of RO (50 and 100 mg/kg) inhibited only the late phase of this test. To further investigate the anti-inflammatory properties of RO, the complete Freund's adjuvant (CFA)- and carrageenan-induced paw inflammation models were used. Pre-treatment with RO (50 and 100 mg/kg) significantly reduced paw edema at 4, 6 and 24 h after the CFA injection. In addition, RO (100 mg/kg) reduced the IL-1 beta, but not TNF-alpha, local production induced by CFA. Administration of RO (25-100 mg/kg) decreased the paw edema induced by carrageenan in rats, which was more evident at 3 and 4 h after induction. In addition, neutrophil migration to the hind paw was measured by MPO assay after the carrageenan injection. The MPO activity was significantly inhibited by RO at 25-100 mg/kg, 4 h after stimulus. In another experimental set, administration of RO (25-100 mg/kg) significantly reduced the leukocyte migration in the carrageenan-induced peritonitis model in mice. The results described here are the first report of pharmacological properties of RO and strongly suggest that RO possesses anti-inflammatory activity related to its ability to inhibit the IL-1 beta production and the leukocyte migration.

• 出版日期2012-12