Association of DNA repair gene polymorphisms with response to cisplatin-based concurrent chemoradiotherapy in patients with cervical carcinoma

作者：Liu, Jin-hui; Xi, Pei; Chai, Yan-lan; Wang, Juan; Wang, Tao; Liu, Zi^*; Dai, Peng-gao^*

来源：DNA Repair, 2016, 41: 69-72.

DOI：10.1016/j.dnarep.2016.03.015

• Cervical carcinoma
• Chemoradiotherapy
• Polymorphisms
• Response
• Exonuclease 1

Purpose: The aim of this study was to investigate polymorphisms in DNA repair genes as potential predictive factors among Chinese cervical cancer patients.
Methods: A total of 72 patients with cervical carcinoma, who received cisplatin-based chemoradiotherapy and whose responses were evaluated by Response Evaluation Criteria in Solid Tumors, were included. The association between response to chemoradiotherapy and the genotypes for 29 single-nucleotide polymorphisms (SNPs) in 25 DNA repair genes were analyzed.
Results: A minor allele of SNP rs9350 in the exonuclease 1 gene was associated with a better response rate, regardless of age and tumor stage (odds ratio, 8.316; p=0.002).
Conclusion: SNP rs9350 in the exonuclease 1 gene is involved in inter-individual differences in the response to cisplatin-based chemoradiotherapy, in patients with cervical carcinoma.

• 出版日期2016-5
• 单位西北大学; 西安交通大学