Association Between Higher Plasma Lutein, Zeaxanthin, and Vitamin C Concentrations and Longer Telomere Length: Results of the Austrian Stroke Prevention Study

作者：Sen Abhijit; Marsche Gunther; Freudenberger Paul; Schallert Michael; Toeglhofer Anna M; Nagl Christoph; Schmidt Reinhold; Launer Lenore J; Schmidt Helena^*

来源：Journal of the American Geriatrics Society, 2014, 62(2): 222-229.

DOI：10.1111/jgs.12644

• telomere length
• vitamin C
• lutein zeaxanthin
• aging
• antioxidants
• oxidative stress

ObjectivesTo examine the association between plasma concentrations of antioxidative micronutrients and leukocyte telomere length (LTL) in elderly adults. %26lt;br%26gt;DesignCross-sectional cohort study. %26lt;br%26gt;SettingAustrian Stroke Prevention Study, a population-based cohort study on brain aging. %26lt;br%26gt;ParticipantsIndividuals with a mean age of 667 (n=786; 58% female). %26lt;br%26gt;MeasurementsConcentrations of vitamin C, lutein, zeaxanthin, -cryptoxanthin, canthaxanthin, lycopene, - and -tocopherol, - and -carotene, and retinol in plasma, advanced oxidation protein products as a measure of oxidative stress in serum, and LTL were measured. Vitamins and carotenoids were measured using high-performance liquid chromatography, advanced oxidation protein products using spectrophotometry, and telomere length using quantitative real-time polymerase chain reaction. %26lt;br%26gt;ResultsMultiple linear regression analyses with adjustment for age and sex demonstrated that higher lutein, zeaxanthin, and vitamin C concentrations were strongly associated with longer telomere length. The associations were independent of body mass index, maximum oxygen uptake, and vascular risk factors and were not mediated by advanced oxidation protein products content. %26lt;br%26gt;ConclusionThis study provides first evidence that higher lutein, zeaxanthin, and vitamin C concentrations in plasma are associated with longer LTL in normal elderly persons and suggest a protective role of these vitamins in telomere maintenance.

• 出版日期2014-2