科研之友
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摘要
alpha,beta-Unsaturated gamma-butyrolactam was reported as the nucleophile for the asymmetric Morita-Baylis-Hillman reaction for the first time. This enantioselective MBH reaction, promoted by chiral bisthiourea with isatins as the electrophile, was carried out under mild conditions, resulting in 3-hydroxyl-2-oxindole derivatives in good to excellent yields and up to 78% ee.
- 出版日期2013
- 单位南京大学
