Association study of COX-2 (PTG.52)-765 G/C. promoter polymorphism by pyrosequencing in Sicilian patients with Alzhetrner%26apos;s disease

作者：Michele Salemi^*; Salluzzo Maria Grazia; Calogero Aldo E; Raffaele Ferri; Bosco Paolo

来源：Archives of Medical Science, 2014, 10(6): 1235-1238.

DOI：10.5114/aoms.2014.47832

• Alzheimer disease
• COX-2 gene
• polymorphism
• pyrosequencing

Introduction: Alzheimer%26apos;s disease (AD) is characterized by progression of memory problems to a slow global decline of cognitive function. Inflammation when left unregulated becomes a major cofactor in the pathogenesis of AD. PTGS2 is of crucial relevance in the inflammatory response, and it has been shown to play a considerable role in AD pathogenesis. %26lt;br%26gt;Material and methods: To assess the possible putative role of a PTGS2 polymorphism (-765 G/C) in AD patients, we examined, by pyrosequencing, its distribution in 84 Sicilian AD patients and in 80 controls. %26lt;br%26gt;Results: No significant statistical difference in PTGS2 765 G/C genotype distribution was found comparing patients with AD and controls. In addition, no significant difference was observed in the distribution of the PTGS2 -765 alleles between AD patients and controls. %26lt;br%26gt;Conclusions: These findings suggest that the PTGS2 -765 G/C polymorphism may not be associated with AD in the Sicilian population.

• 出版日期2014-12