An efficient InCl3-catalyzed hydration of nitriles to amides: acetaldoxime as an effective water surrogate

作者：Kim Eun Sun; Lee Hyun Seung; Kim Sung Hwan; Kim Jae Nyoung^*

来源：Tetrahedron Letters, 2010, 51(12): 1589-1591.

DOI：10.1016/j.tetlet.2010.01.063

• Indium chloride
• Hydration
• Nitriles
• Amides
• Acetaldoxime

An efficient InCl3-catalyzed hydration protocol of nitrites to amides was developed. The reaction was carried Out in toluene at refluxing temperature with the aid of acetaldoxime as an effective water surrogate to produce amides in high yields.

• 出版日期2010-3-24