Novel Use of Pharmacogenetic Testing in the Identification of CYP2C9 Polymorphisms Related to NSAID-Induced Gastropathy

作者：Gupta Anita^*; Zheng Lu; Ramanujam Vendhan; Gallagher John

来源：Pain Medicine, 2015, 16(5): 866-869.

DOI：10.1111/pme.12654

• Efficacy
• Outcomes
• NSAIDs
• CP450
• CYP2C9
• Pharmacogenetic Testing
• Gastropathy

ObjectiveTo illustrate the potential value of pharmacogenetic testing to identify patients at risk for nonsteroidal anti-inflammatory drug-induced gastropathy.
DesignCase report.
SettingWe report a case encountered in an outpatient setting for pain management.
PatientWe present a case of a patient treated with celecoxib who developed severe nonsteroidal anti-inflammatory drug-induced gastropathy.
InterventionSuspecting a relation between this adverse event and altered drug metabolism, pharmacogenetic testing was performed to assess the role of the cytochrome P450 (CP450) enzyme profile.
ResultsPharmacogenetic testing revealed a relation between this adverse event and an allelic variant of cytochrome P450, CYP2C9, subsequently leading to discontinuation of the drug along with counseling to caution the patient to avoid the use of celecoxib and other drugs metabolized by the same enzyme.
ConclusionAlthough pharmacogenetic testing is not routinely used in clinical decision making, pain physicians must be aware of the potential benefits of this testing for managing patients with pain, and to improve drug efficacy and safety profile.

• 出版日期2015-5