Methods for the Synthesis of Substituted Azetines

作者：Baumann Andreas N; Eisold Michael; Music Arif; Haas Geoffrey; Kiw Yu Min; Didier Dorian^*

来源：Organic Letters, 2017, 19(20): 5681-5684.

DOI：10.1021/acs.orglett.7b02847

Spurred on by the recent emerging interest from the chemical community for unsaturated four-membered heterocycles, an unprecedented approach to nitrogen-containing four-membered rings has been designed. 3,4-Disubstituted 2-azetines were synthesized from commercially available substrates, allowing for a straightforWard access to a new library of chiral functionalized azetidines and amino alcohols. This original approach was applied to efficiently prepare functionalized azobenzenes, an emerging class of molecules with a large potential in photopharmacology.

• 出版日期2017-10-20