Novel Silicone-Coated I-125 Seeds for the Treatment of Extrahepatic Cholangiocarcinoma

作者：Lin, Lizhou; Guo, Lili; Zhang, Weixing; Cai, Xiaobo; Chen, Dafan; Wan, Xinjian^*

来源：PLos One, 2016, 11(2): e0147701.

DOI：10.1371/journal.pone.0147701

• MALIGNANT BILIARY OBSTRUCTION
• BRUSH CYTOLOGY
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I-125 seeds coated with titanium are considered a safe and effective interstitial brachytherapy for tumors, while the cost of I-125 seeds is a major problem for the patients implanting lots of seeds. The aim of this paper was to develop a novel silicone coating for I-125 seeds with a lower cost. In order to show the radionuclide utilization ratio, the silicone was coated onto the seeds using the electro-spinning method and the radioactivity was evaluated, then the anti-tumor efficacy of silicone I-125 seeds was compared with titanium I-125 seeds. The seeds were divided into four groups: A (control), B (pure silicone), C (silicone I-125), D (titanium I-125) at 2 Gy or 4 Gy. Their anti-tumour activity and mechanism were assessed in vitro and in vivo using a human extrahepatic cholangiocarcinoma cell line FRH-0201 and tumor-bearing BALB/c nude mice. The silicone I-125 seeds showed higher radioactivity; the rate of cell apoptosis in vitro and the histopathology in vivo demonstrated that the silicone I-125 seeds shared similar anti-tumor efficacy with the titanium I-125 seeds for the treatment of extrahepatic cholangiocarcinoma, while they have a much lower cost.

• 出版日期2016-2-3
• 单位上海交通大学