High circulating microRNA-122 expression is a poor prognostic marker in patients with hepatitis B virus-related hepatocellular carcinoma who undergo radiofrequency ablation

作者：Cho Hyo Jung; Kim Jai Keun; Nam Ji Sun; Wang Hee Jung; Lee Jei Hee; Kim Bong Wan; Kim Soon Sun; Noh Choong Kyun; Shin Sung Jae; Lee Kee Myung; Cho Sung Won; Cheong Jae Youn^*

来源：Clinical Biochemistry, 2015, 48(16-17): 1073-1078.

DOI：10.1016/j.clinbiochem.2015.06.019

• MicroRNA-122
• Hepatocellular carcinoma
• Radiofrequency ablation
• Prognosis

Objectives: Aim of this study was to investigate the prognostic potential of plasma microRNA-122 levels in patients with hepatitis B virus (HBV)-related hepatocellular carcinoma after hepatic resection or radiofrequency ablation (RFA).
Design and methods: A total of 120 patients with HBV-related hepatocellular carcinoma who underwent hepatic resection (n = 63) or RFA (n = 57) were included. The pretreatment plasma microRNA-122 level was assessed using quantitative real time polymerase chain reaction, and the correlation between microRNA-122 expression and various clinical parameters was investigated.
Results: Multivariate Cox regression analysis demonstrated that, in all patients, a low platelet count (<100 x 10(9)/L), low albumin level (<= 3.5 g/dL.), and advanced tumor stage (modified Union for International Cancer Control stage III/IV) were independent prognostic factors for disease-free survival, while a low albumin level and advanced tumor stage were independent prognostic factors for overall survival (OS). In a subgroup analysis of patients who underwent RFA, the patients with high miR-122 expression (>100) had significantly lower OS on Kaplan-Meier analysis (P = 0.042). Furthermore, high microRNA-122 expression (hazard ratio [HR] = 2.67; 95% confidence interval [CI] = 1.12-6.35; P = 0.026) and advanced tumor stage (HR = 2.27; 95% CI = 1.23-4.18; P = 0.009) were independent risk factors for poor OS in patients treated with RFA. The combination of microRNA-122 and tumor stage resulted in an area under the curve of 0.818 for predicting 1-year OS in patients who underwent RFA.
Conclusions: High plasma microRNA-122 expression was associated with poor OS in patients with HBV-related hepatocellular carcinoma who underwent RFA.

• 出版日期2015-11