A validation study of the Chinese wearing off questionnaire 9-symptom for Parkinson's disease

作者：Chan A; Cheung Y F; Yeung M Au; Yeung J; Chung T H; Tsang K L; Chan J; Lau C; Kwan P; Kuo Sheng Han; Mok V^*

来源：Clinical Neurology and Neurosurgery, 2011, 113(7): 538-540.

DOI：10.1016/j.clineuro.2011.03.007

• Chinese
• Parkinson's disease
• Wearing off questionnaire

Objective: Development of wearing off (WO) often goes unnoticed for both patients with Parkinson's disease (PD) and physicians due to the complexity of this phenomenon. A brief 9-symptom WO questionnaire (WOQ-9) was recently found to be highly sensitive in its detection. We aimed to validate a Chinese version WOQ-9 (CWOQ-9) among Chinese patients with PD.
Methods: We recruited 101 literate Chinese PD patients among 4 different neurology or movement disorders clinics in Hong Kong to participate in this study by completing the CWOQ-9. Clinical judgment by the specialists was considered the gold standard for diagnosing WO.
Results: The mean age (+/- SD) of the patients was 61 (+/- 9) years and 35(34.7%) of them were female. The disease duration was 7.4 (+/- 5.4) years and 69(68.3%) of them were diagnosed clinically to have WO by the specialists. The positive and negative predictive values, sensitivity and specificity of CWOQ-9 were 86%, 71%, 87%, and 69% respectively. The area under curve (AUC) was 0.78 (p < 0.001).
Conclusion: This simple patient questionnaire is a valid tool for the detection of WO among Chinese PD patients.

• 出版日期2011-9
• 单位香港中文大学