A Practical Approach to New (5Z) 2-Alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one Derivatives

作者：Bourahla Khadidja; Paquin Ludovic; Lozach Olivier; Meijer Laurent; Carreaux Francois; Bazureau Jean Pierre^*

来源：Molecules, 2011, 16(9): 7377-7390.

DOI：10.3390/molecules16097377

• 1,5-dihydro-4H-imidazol-4one
• Knoevenagel condensation
• microwave irradiation
• S-alkylation

A practical protocol for the preparation of (5Z)-2-alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one derivatives is reported. The new compounds were obtained in good yield and stereoselectivity in two steps, namely a solvent-free Knoevenagel condensation under microwave irradiation, followed by an S-alkylation reaction with various halogenoalkanes.

• 出版日期2011-9