A practical solution-phase synthesis of an antagonistic peptide of TNF-alpha based on hydrophobic tag strategy

作者:Tana Gegen; Kitada Shingo; Fujita Shuji; Okada Yohei; Kim Shokaku; Chiba Kazuhiro*
来源:Chemical Communications, 2010, 46(43): 8219-8221.
DOI:10.1039/c0cc03090b

摘要

A simple acid-resistant hydrophobic tag, which can be removed rapidly in a single-step procedure after overall peptide synthesis, has been developed to accomplish practical solution-phase synthesis of a 15-mer antagonistic peptide of TNF-alpha (A-TNF-alpha). Hydrophobically tagged peptides can be separated as precipitates at each step by addition of a polar organic solvent.

  • 出版日期2010